PROGRAMME to download (see below)

e organizing committee elected following abstracts for inclusion in the program
for abstract talks:

Session 1- Novel Strategies:
FC engineered antibody CD19-DE eradicates MRD in patient-derived infant acute lymphoblastic leukemia xenografts by engagement of myeloid effector cells (Peipp)

Session 2 - Metastasis:
The role of DNA repair defects in chromothripsis

Session 3 - Targeted Immunotherapy:
Combined blockade of PD1 and CD96 checkpoints leads to improved long-term survival after surgical resection of pancreatic adenocarcinoma in mice

Session 4 - Targeting transcription and Chromatin:
N-MYC-dependent pause release of RNA polymerase II is controlled by association with Aurora -A during the cell cycle

Session 5 - Hereditary Cancer:
No benefit of annual colonoscopic surveillance intervals on colorectal cancer incidence and tumor stage in Lynch syndrome: A combined analysis of data from Germany, the Netherlands, and Finland


Flash-Talks on Wednesday, June 14th:

Al-Batran: Perioperative chemotherapy with docetaxel, oxaliplatin, and fluorouracil/leucovorin (FLOT) versus epirubicin, cisplatin, and fluorouracil or capecitabine (ECF/ECX ) for resectable gastric or gastroesophageal junction (GEJ) adeno carcinoma (FLOT4-AIO): A multicenter, randomized phase 3 trial.

Bhatti: Discovery of a synergistic combination of Smacmimetic and Bortezomib to trigger necroptosis in Bcell non-Hodgkin lymphoma cells

Brinker: Photoaging smartphone apps for skin cancer prevention in German adolescents: the Sunface randomized trial

Cekay: Synergistic cell death by SMAC-mimetics and type II interferons

Chauvistré: Phenotypic modulation as a new therapeutic strategy in melanoma

De Bruyn: Identifying druggable vulnerabilities of RB1-deficient tumors with a novel FDA-drug target CRISPR/Cas library

Enßle: Combinatorial targeting of gene expression with BET- and HDAC- inhibitors induces synergistic cell death in habdomyosarcoma

Gerke: Systematic identification of cancer-specific immunogenic peptides with RAVEN

Flash-Talks on Thursday, June 15th:

A. Jahn: ZBTB48 has a dual function: telomere length limitation and transcriptional regulation

Janssen: Dual specifi city phosphatase 5 (DUSP5) as metastasis suppressor in colorectal cancer

Johnsen: Histone deacetylase class-Iinhibition promotes epithelial gene expression in pancreatic
cancer cells in a BRD4- and MYC-dependent manner

Kolbinger: Development of novel HDAC inhibitors to selectively co-inhibit HDAC8 and HDAC10 in childhood cancer

Menssen: Genetic inactivation of Sirt1 function in Eμ-Myc mice reveals crucial role for p53 pathway regulation and lymphomagenesis

Radlwimmer: BCAA catabolism by BCAT1 controls intracellular 2-OG levels and cell proliferation

Ruess: PTPN11 drives tumor development and defines a novel therapeutic target in KRAS-mutant cancers

Thivakaran: Gfi 1b – A novel tumorsuppressor in acute myeloid leukemia




June 14th - 16th, 2017

Maritim Hotel Bonn,